A Method for the Detection of Chromosomal Aneuploidies
The non-invasive detection of fetal chromosomal aneuploidies is demonstrated. Alleles of fetal RNA-SNPs present in a biological sample (e.g. maternal blood) containing fetal RNA are detected and quantified in order to determine the ratio of the alleles. This ratio is compared to a standard control consisting of euploid fetuses. Deviation of allele ratio indicates the presence of chromosomal aneuploidy.
Patent Number: US7645576B2
Application Number: US2006384128A
Inventor: Lo, Yuk-Ming Dennis | Chiu, Rossa Wai Kwun | Tsui, Bo Yin | Ding, Chunming | Cantor, Charles
Priority Date: 18 Mar 2005
Priority Number: US7645576B2
Application Date: 17 Mar 2006
Publication Date: 12 Jan 2010
IPC Current: C07H002104 | C12Q000168
US Class: 43500611 | 435006 | 43500612 | 43500617 | 4350911 | 4350912 | 5360231 | 5360243
Assignee Applicant: The Chinese University of Hong Kong
Title: Method for the detection of chromosomal aneuploidies
Usefulness: Method for the detection of chromosomal aneuploidies
Summary: The method (M1) is useful for detecting the presence of a chromosomal disorder in the fetus of a pregnant woman (claimed).
Novelty: Detecting chromosomal disorder in fetus of pregnant woman by detecting increase or decrease in ratio of RNA transcribed from genetic locus from chromosome of concern in RNA-containing sample of pregnant woman, compared to standard
診斷/治療
其他疾病
04/MED/181
Inventor(s): Professor Dennis Yuk Ming LO, Department of Chemical Pathology
Patent Status: Taiwanese Patent Pending US Patent Pending PCT Application Filed
香港
