Ex Vivo Maintenance and Expansion Of Hematopoietic Stem Cells
The discovery offers a unique method and novel approach that enables ex vivo expansion of adult HSCs. It also allows for long-term maintenance of HSCs culture without a loss of their regenerative activity.
The invention enables the prolonged maintenance and expansion of HSCs in culture. This could support the expansion or treatment of adult HSCs prior to transplantation. It could also provide a safe and effective platform to test drugs on adult HSCs. The invention could also provide a platform that enables efficient genetic modification/editing of adult HSCs, which could facilitate the treatment of genetic blood disorders and enhance the generation of engineered cell and immune therapy products.
Researchers at UC San Diego have discovered and pioneered a method to maintain and expand adult HSCs ex vivo. This method utilizes interventions that modulate protein biogenesis and homeostasis pathways that are essential for stem cell self-renewal, but that become dysregulated in culture. Experiments have demonstrated that the method fully supports robust maintenance and expansion of HSCs in culture for at least 10 days. Cultured HSCs completely maintain their regenerative capacity as they are fully competent to give long-term multilineage reconstitution upon serial transplantation.
State Of Development The invention is in the experimental data stage. Intellectual Property Info This technology is patent pending and available for licensing and/or research sponsorship. Tech ID/UC Case 29637/2017-337-0 Related Cases 2017-337-0
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