Sortilin-Binding Small Molecule Increases Glucose Uptake
Increase glucose uptake, Treat diabetic patients, Address obesity in diabetics
The inventors identified various scaffolds of small molecules with the ability to dock at a site within sortilin to promote the increase of glucose uptake. These scaffolds include norbornene anhydride amino acid adducts, phenyl-amide-acids of benzyl substituted glutaric acids, and 2-substituted 3-oxo-1,2,3,4-tetrahydro -2-quinoxalines. The compounds are identified by their ability to suitably bind to a region of the sortilin protein with high affinity and thereby mediate the interaction ofsortilin with various protein molecules or other natural substrates. Compounds of three scaffolds, according to embodiments of the invention, are observed to bind tosortilin both in vivo and in silico. These sortilin ligands increase can be employed in compositions to increase uptake of glucose for the treatment of diabetic patients.
美国
