LRBA: A Sensitive Biomarker and Effective Therapeutic Target for Inflammatory Diseases
Noninvasive biomarkerSafe and efficient therapyCardiovascular relevance
pro-inflammatory marker and therapeutic strategy
Our inventors have determined that LRBA is a master regulator for many important genes involved in immune disorder such as autoimmunity, immunodeficiency and other inflammatory diseases. Since LRBA levels in healthy controls and patients with controlled symptoms are virtually undetectable, LRBA serves as a convenient noninvasive biomarker. LRBA also possibly could be used as a therapeutic target through giving intravenous injections to replenish LRBA in patients who lack functional LRBA. Conversely, in the event of LRBA over-expression, which may cause inflammation, LRBA antibodies or LRBA dominant negative mutants (DNM) possibly could be used to block LRBA function to treat inflammatory diseases such as cardiovascular disease, a complex chronic inflammatory disease, since LRBA is highly expressed in the heart.
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