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2,4-Diaminoquinazolines as Anti-Bacterials


技术优势

Minimum Inhibitory Concentration < 1 mMLibrary of compounds shown to be effective against Methicillin Resistant Staphylococcus aureusLimited toxicity and very low levels of resistance to their activity


技术应用

antibiotic agents against Staphylococcal infections


详细技术说明

Our inventors have synthesized a novel library of compounds which have shown to be effective against Methicillin resistant Staphylococcus auerus (MRSA) with the most active compounds having minimum inhibitory concentration (MIC) < 1mM. Gene sequencing of the few mutants formed using the most active compounds suggests a novel mechanism of action, as the target was shown not to be those commonly associated with these agents, including topoisomerase, gyrase, and dihydrofolate reductase.The novel compounds provided from this invention have the potential to be useful as novel antibiotic agents against Staphylococcal infections as they try to overcome the problem of antibiotic resistance. This invention is directly applicable to the field of antibiotics and antimicrobials thereby contributing to medicine and healthcare.


国家/地区

美国

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