Nucleotide-based Carbohydrate Vaccines
Powerful method to produce vaccineExhaustive antigen epitope spaceHigh throughput
Pharmaceutical - vaccine development
The invention relates to a method of directedevolution of a large library of carbohydrate-oligonucleotide conjugates, andthen a therapeutically-useful monoclonal antibody is used to bind those membersof the library which best resemble its native epitope. Through amplification ordiversification of the best binders from the first library, the best epitopemimics are selected from subsequent library generations to provide improvedbinders. The carbohydrate-oligonucleotide conjugates obtained from the processpresent carbohydrates in an environment similar to that of the natural epitope.Such a compound, when formulated with the appropriate immunogenic carrier andadjuvant, would constitute a vaccine.
United States
9,080,169
美国
