Monoclonal antibody panel against surface epitopes of several strains of M. gallisepticum (10 lines)
ApplicationsThese10 IgG monoclonal antibodies were generated against various strains of Mycoplasma gallisepticum and recognize M. gallisepticum surface epitopes, andtheir use has been validated for ELISA, DIBA, immunoblotting, immunoperoxidaseassay and Haemagglutination Inhibition applications, and have the potential tobe used in therapeutic measures.Mycoplasmagallisepticum (Mg) is a bacterium belonging to the class Mollicutes and thefamily Mycoplasmataceae. It is thecausative agent of chronic respiratory disease (CRD) in chickens and infectioussinusitis in turkeys, chickens, game birds, pigeons, and passerine birds,causing some level of mortality. Once infected, they are carriers for thedisease for life. Since the disease causes reduced feed and growth production,carcass condemnations, and retarded growth in juveniles, serious economiclosses have occurred. Also, chickens have been documented to lose about 16 eggsover their laying cycle of 45 weeks. Mycoplasma lack cell walls, have highlyvariable surface proteins and a distinctive plasma membrane, and are thesmallest self-replicating prokaryotes. Mycoplasma can cause disease in humans,animals, insects, and plants. Isolates of Mycoplasmagallisepticum vary widely in their pathogenicity depending on the nature ofthe isolate, its method of propagation, and the number of passages. Among Mgstrains significant differences have also been observed in their tissuetropism, transmission and in the immune response they induce.
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