UCLA Inventors Create Platform Technology to Create Customizable Nanoscale Wound Management Tools
Hydrogel version is thermoresponsive – an injectable liquid at room temp, solid at body temp Hydrogel possesses nano and microscale network to allow cell attachment and proliferation Able to load vesicles and hydrogels with hydrophilic and/or hydrophobic payloads Potential low toxicity and biodegradability due to synthetic polymerized peptide building block Vesicles can penetrate cell membranes to intracellularly deliver payloads Stable at high temperature (up to 80°C in water) and can be engineered to various sizes (50 to 1000nm) Inexpensive starting material and process chemistry used to synthesize peptidic polymers
With the increasing elderly population, the wound management market has been greatly affected, primarily due to the increase incidents of skin ulcers and surgical procedures. The wound management market has begun investing heavily in advanced dressing technologies as a means to address the rise in healthcare costs.These advanced dressing technologies include materials to deliver cells to the wound site; materials to deliver proteins, such as collagen, to the wound; and materials to act as artificial skin or as skin replacement. Many of these advanced materials are based on nanoscale gels and vesicles as a means to adhere to the wound at the cellular level. These nanoscale systems offer the promise of minimizing toxicity, maximizing bioavailability, and potentially reducing scarring.
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Other Information References: UCLA Cases 1998-072, 2001-307, 2007-014, 2008-767, 2012-598, 2013-315, 2015-124, 2015-452, 2015-612 Deming Group: http://deming.seas.ucla.edu/ For further information on this innovation, contact: Additional Technologies by these Inventors Tech ID/UC Case 25501/2015-124-0 Related Cases 2015-124-0
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