Novel Method to Spatially Program Stem Cell Fate
• Hydrogels can be used as a platform for developing synthetic niches for various stem cells and stem cell cultures• Commercialized kits can be sold to enable a consumer to immobilize a particular molecule of interest• Hydrogel substrates provide the immobilization of the bioactive signal at desired locations with spatial control• The current technology is able to incorporate more bioactive signals without compromising the hydrogel formation
Stem cells are capable of both self-renewing and differentiating into more specialized cells. These two defining characteristics make stem cells a powerful tool for biological research, as they provide the potential to regenerate tissue in a living organism and grow organs in culture.Our ability to probe human stem cell fate has been hindered by the inability to create cellular microenvironments that provide a platform to spatially program stem cell fate. The invention described here provides the cellular microenvironment required to investigate the signaling molecules involved in the induction of stem cell fate.
State Of Development Additional Technologies by these Inventors Tech ID/UC Case 22462/2011-100-0 Related Cases 2011-100-0
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