Improved Immunization Strategy Using Recombinant BCG Vaccines

1. The use of a booster protein augments the immunoprotective effects of BCG, the most widely administered TB vaccine.2. Billions of people have already been vaccinated with BCG, and approximately 100 million newborns and infants are vaccinated annually. Thus use of the booster can be easily integrated into current vaccination protocols.3. The booster protein is a member of a group of proteins that have been shown to be immunoprotective against M. tuberculosis.4. The booster proteins have been shown to be abundantly expressed in rapidly- growing recombinant nonpathogenic bacteria and have been purified in large amounts from cultures of such recombinant bacteria.

The booster can be used to augment immunity against M. tuberculosis and other mycobacteria (e.g. M. avium, a cause of pneumonia in immunocompromised patients such as AIDS patients, and M. leprae, the agent of leprosy). The vaccine is administered via injection (intradermally, subcutaneously, etc.)

Researchers at UCLA have developed an improved vaccination strategy for people previously immunized with BCG or to be immunized with BCG in the future. In effect, the improved vaccination strategy involves priming with BCG and boosting with a protein that is administered separately during a subsequent vaccination(s). The use of this prime-boost strategy dramatically enhances protective immunity in an animal model. Thus the improved strategy described here utilizes a booster protein in subsequent vaccinations to increase efficacy and prolong protection.

Patent Number: US7622107B2
Application Number: US2003595385A
Inventor: Horwitz, Marcus A. | Harth, Gunter
Priority Date: 16 Oct 2003
Priority Number: US7622107B2
Application Date: 13 Apr 2006
Publication Date: 24 Nov 2009
IPC Current: A01N006500 | A61K003900 | A61K003902 | A61K003904 | A61K003938 | C12N001500
US Class: 4240931 | 4241841
Assignee Applicant: The Regents of the University of California
Title: Recombinant intracellular pathogen immunogenic compositions and methods for use
Usefulness: Recombinant intracellular pathogen immunogenic compositions and methods for use
Summary: The immunogenic composition is useful in a vaccine strategy for inducing an immune response in host.
Novelty: New immunogenic composition comprising a recombinant BCG comprising extrachromosomal nucleic acid encoding Mycobacteria major extracellular proteins, useful in a vaccine strategy for inducing an immune response

生物医学

DNA /基因工程

8124068

State Of Development

The strategy of boosting BCG with a booster protein has been tested in vivo in the highly relevant and stringent guinea pig model of pulmonary tuberculosis.

Background

Tuberculosis (TB) remains one of the world's most important infectious diseases. The causative agent, Mycobacterium tuberculosis, is the leading cause of death of any infectious agent. Each year, approximately 8 million people develop active pulmonary TB and two million die from this disease. The World Health Organization (WHO) has declared TB a global health emergency, the first disease so designated. Compounding the problem, strains of M. tuberculosis resistant to the major antibiotics used to treat tuberculosis are rapidly emerging worldwide. This has given new urgency to the need to develop an effective prophylaxis for TB. Vaccination is particularly important for developing nations and at-risk populations.

Four billion people in the world have been vaccinated with the currently used vaccine, bacille Calmette-Guerin or BCG, and approximately 100 million additional individuals are vaccinated with BCG each year. Since BCG provides only partial immunity to tuberculosis, these people could benefit from a booster vaccine that enhances their level of protection against tuberculosis.

 

Related Materials

Additional Technologies by these Inventors

• New Recombinant Tuberculosis BCG Vaccine for Immunocompromised Patients and Others
• Recombinant Tuberculosis BCG Vaccine Elicits a Highly Protective Host Immune Response
• Method of Producing Novel Unmarked Recombinant Vaccine Vector for Tuberculosis
• Safe and Potent Vaccines against Tularemia
• Novel Vaccines Against Tularemia
• Novel Live Recombinant Booster Vaccine against Tuberculosis
• Live Recombinant Tuberculosis Vaccine

Tech ID/UC Case

21724/2004-046-0

Related Cases

2004-046-0

美国

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