Translation Factors as Anti-aging Drug Targets
Specific target for anti-aging compound screens may enable rationale design of drug targets
Anti-aging drug target for the treatment of aging diseases, such as diabetes, cancers, Alzheimers diseases and other neurogenerative diseases. New assay for anti-aging drug discovery
Researchers at UCLA have identified the molecular target of resveratrol, thereby uncovering a new drug target for anti-aging drug screening. Additionally, this target has been indirectly implicated in anti-aging research in S. cerevisiae and C. elegans, and inhibitors of this target have previously been identified. These inhibitors may be useful candidates for future anti-aging drugs.
Patent Number: US20110288153A1
Application Number: US13129539A
Inventor: Huang, Jing | Hao, Rui | Lomenick, Brett Eugene | Jonai, Nao | Diep, Simon
Priority Date: 18 Nov 2008
Priority Number: US20110288153A1
Application Date: 4 Aug 2011
Publication Date: 24 Nov 2011
IPC Current: A61K0031713 | A61K0031429 | A61K00315575 | A61K003158 | A61K00317088 | A61P000300 | C12Q000134 | C12Q000168 | C40B003004 | G01N0033566
US Class: 514044A | 43500611 | 4350071 | 43500792 | 435018 | 506009 | 514173 | 514368 | 514559
Assignee Applicant: The Regents of the University of California
Title: TRANSLATION FACTORS AS ANTI-AGING DRUG TARGETS
Usefulness: TRANSLATION FACTORS AS ANTI-AGING DRUG TARGETS
Summary: The method is useful for slowing aging, increasing healthspan in mammal, and screening an agent for inhibiting aging, where the mammal includes human or non-human mammal (all claimed).
Novelty: Slowing aging, involves administering agent capable of inhibiting expression and/or activity of eukaryotic initiation factor 4A excluding resveratrol to mammal e.g. human
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State of Development The molecular target of resveratrol has been identified. Its use as a readout for anti-aging drug discovery has been validated in vitro. The existing inhibitors to the target have not been tested for their ability to prolong survival in the laboratory. Background Aging is a natural state of development that reduces ones adaptivity and increases the incidence of disease. Several diseases, including cancer, atherosclerosis and neurodegeneration, occur as a direct result of aging. Resveratrol is a well known anti-aging chemical, but its molecular target is controversial, making it difficult to uncover other chemicals. It would be of interest to discover resveratrols target within the cell to allow a new class of anti-aging drugs to emerge. Related Materials Target identification using drug affinity responsive target stability (DARTS) Tech ID/UC Case 20436/2009-302-0 Related Cases 2009-302-0
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