Methods to Expand Natural Regulatory T cells (nTreg) with Immunodominant Fc Peptides
The use of these immunomodulatory synthetic peptides provide significant advantages over IVIG: cheaper product to manufacture and cheaper treatment since it does not require hospitalization; the product is more stable and reproducible; and is safer (synthetic peptides in the market approved by the FDA have shown to be safe and well-tolerated
Researchers at UC San Diego have identified a set of 16 immunodominant Fc peptides (that were narrowed down to a 3-5 peptide combination), which induces the expansion of nTreg in vivo. These Fc-specific nTregs cells are present in natural donors and in KD patients who responded well to the IVIG treatment; however, this cell population is not present in IVIG-non-responding KD patients. In vitro studies suggest that these Fc immunodominant peptides can overcome this unresponsiveness, which is most likely due to a defect of the antigen processing of the Fc regions of immunoglobulins that are responsible for the expansion of nTreg cells. Although other alternative therapies to IVIG are under study (e.g. corticosteroids, infliximab, cyclosporine A, anakinra, atorvastatin), these are expensive and induce a more general and strong immunosuppression in patients with the corresponding unwanted side effects. The identified immunodominant Fc peptides provide a more specific immunoregulatory response in the patient without inducing a massive/ generalized immunosuppression.
10035823
State Of Development Human studies on an expanded group of Rheumatoid Arthritis patients with selected peptides is ongoing. Intellectual Property Info A patent application has been filed: US20170260236 Related Materials Tech ID/UC Case 25131/2015-050-0 Related Cases 2015-050-0
美国
