Extracellular matrices and methods for treating peripheral artery disease (PAD)
Researchers at the University of California, San Diego have developed tissue specific decellularized matrices for treating peripheral artery disease, critical limb ischemia, and have potential for skeletal muscle tissue engineering. Mammalian extracellular matrix provides scaffolds for cell growth, recruitment and replacement as well as a biocompatible material that can be used to deliver drugs to specific tissues (e.g. skeletal myoblasts, stem cells, and other cell types relevant to skeletal muscle repair).
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Related Materials DeQuach JA, Mezzano V, Miglani A, Lange S, Keller GM, Sheikh F, Christman KL. Simple and high yielding method for preparing tissue specific extracellular matrix coatings for cell culture. PLoS One. 2010 Sep 27;5(9):e13039. Tech ID/UC Case 22431/2012-053-0 Related Cases 2012-053-0
Singelyn JM, DeQuach JA, Christman KL. Injectable myocardial matrix as a scaffold for myocardial tissue engineering. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:2406-8
Singelyn JM, DeQuach JA, Seif-Naraghi SB, Littlefield RB, Schup-Magoffin PJ, Christman KL. Naturally derived myocardial matrix as an injectable scaffold for cardiac tissue engineering. Biomaterials. 2009 Oct;30(29):5409-16
Singelyn JM, Sundaramurthy P, Johnson TD, Schup-Magoffin PJ, Hu DP, Faulk DM, Wang J, Mayle KM, Bartels K, Salvatore M, Kinsey AM, Demaria AN, Dib N, Christman KL. Catheter-deliverable hydrogel derived from decellularized ventricular extracellular matrix increases endogenous cardiomyocytes and preserves cardiac function post-myocardial infarction. J Am Coll Cardiol. 2012 Feb 21;59(8):751-63.
Young DA, DeQuach JA, Christman KL. Human cardiomyogenesis and the need for systems biology analysis. Wiley Interdiscip Rev Syst Biol Med. 2011 Nov-Dec;3(6):666-80.
Hydrogel helps hearts heal after myocardial infarction in animals, taking step toward trials in human heart-attack patients. San Diego Biotechnology Connection News Release (Rex Graham)
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