High Throughput Protein 3D Structure Determination Employing Enhanced Amide Deuterium Exchange Mass Spectrometry (DXMS)
This technology is especially adapted to utilize data acquired and processed by existing high-throughput instrumentation, chemistries, and software ("DXMS") recently developed at UC San Diego.
UC San Diego researchers have invented a technique for high-resolution 3D protein structure determination that breaks through the limitations presented by crystallographic and NMR-based techniques. The method uses rapidly acquired, high-resolution amide deuterium exchange-mass spectrometric (DXMS) experimental data that has been obtained from microgram quantities of soluble protein in order to provide constraints sufficient to determine a protein's high-resolution 3D structure.
生物医学
DNA /基因工程
Intellectual Property Info See U.S. patent application number 10/577,179. Tech ID/UC Case 22001/2003-105-0 Related Cases 2003-105-0, 2002-108-0, 2002-157-0, 2003-107-0
美国
