Polymeric Nano-Carriers with a Linear Dual Response Mechanism to Detect Disease
Potential advantages from molecular engineering linear dual-response mechanisms in the backbone of polymeric nanoparticles include enhanced stability and prolonged shelf life, while also increasing the response sensitivity and efficacy of targeted delivery to diseased environments. In addition, this polymeric nano-carrier technology may reduce overall toxicity by decomposing into easily excretable fragments.
Researchers from UC San Diego have designed ‘smart’ or ‘sensing’ nanoprobes (polymeric nano-carriers) responsive to pH and hydrogen peroxide stimuli, useful for amplifying contrast activation. Specifically, this technology comprises research designs and methods to deactivate and reactivate the contrast signal of magnetic resonance imaging (MRI) contrast agents and near infrared (NIR) contrast agents by the use of encapsulated dual response nano-carriers.
Patent Number: US8758778B2
Application Number: US13234969A
Inventor: Almutairi, Adah | Sankaranarayanan, Jagadis | Mahmoud, Enas | Schopf, Eric
Priority Date: 16 Sep 2010
Priority Number: US8758778B2
Application Date: 16 Sep 2011
Publication Date: 24 Jun 2014
IPC Current: A61K000900 | A61B0005055 | A61K003800
US Class: 424400 | 4240093 | 42400936 | 5140011
Assignee Applicant: The Regents of the University of California
Title: Polymeric nano-carriers with a linear dual response mechanism and uses thereof
Usefulness: Polymeric nano-carriers with a linear dual response mechanism and uses thereof
Summary: The compositions is useful for delivering a payload (protein or DNA) to a tissue, (claimed) within the patient by responding to lower pH and/or reactive oxygen species at localities within the patient by nano-carriers.
Novelty: Composition useful for delivering payloads to e.g. specific areas or organs within patient, comprises logic gate nano-carrier having polymer comprising response element that responds to lower pH or reactive oxygen species
生物医学
DNA /基因工程
8758778
Tech ID/UC Case 21771/2010-189-0 Related Cases 2010-189-0
美国
