A Novel Nitric-Oxide Releasing Drug
Direct release of NO at physiological temperature and pH. More potent than equimolar amounts of nitroglycerin. Development of patient tolerance should not occur. No toxic by-products or concurrently released agents. Repeated administration regimens or development of time released formulations possible.
This hypertensive agent, nitrosyl-cobinamide, is a direct NO releasing agent that does not require biotransformation, thereby avoiding the concurrent release of toxic metabolites (superoxide ions, peroxynitrate, or cyanide ions). Cobinamide is a precursor of Vitamin B12 and appears to be metabolically neutral at the doses used for this indication. It has been tested in mammalian cells, Drosophila melanogaster and mice, where a rapid reduction of blood pressure was demonstrated.
Patent Number: US9093654B2
Application Number: US13022242A
Inventor: Che, Chi Ming | Xiang, Hai Feng
Priority Date: 9 Feb 2010
Priority Number: US9093654B2
Application Date: 7 Feb 2011
Publication Date: 28 Jul 2015
IPC Current: H01L005146 | B82Y001000 | H01L00310224 | H01L005100 | H01L005130 | H01L005142
US Class: 1001
Assignee Applicant: The University of Hong Kong
Title: Bis-(8-quinolinolato-N,O)platinum(II) based organic photovoltaic cell
Usefulness: Bis-(8-quinolinolato-N,O)platinum(II) based organic photovoltaic cell
Summary: The organic photovoltaic cell is useful to generate electricity.
Novelty: Organic photovoltaic cell, useful to generate electricity, comprises an organic photoactive layer comprising substituted bis-(8-quinolinolato-N,O)platinum(II) complexes
功能设计
机械结构
8222242
State Of Development Development for the use of this compound is at the prototype stage and efficacy in reducing blood pressure has been demonstrated. Ongoing pre-clinical studies continue, including pharmacokinetic and toxicology. Additional Technologies by these Inventors Tech ID/UC Case 19637/2007-196-0 Related Cases 2007-196-0
美国
