Immunomodulatory Materials For Implantable Medical Devices
This study provides critical evidence demonstrating that the immunomodulatory molecule coated onto biomaterial surfaces functions to mitigate the inflammatory response. Importantly, we observed an inhibitory effect using multiple in vitro and in vivo models. This work may potentially lead to a new paradigm for materials used in biomedical implants, where materials are designed to actively modulate local immune response through specific molecular interactions with surface receptors expressed by immune cells. This strategy is also currently being explored for the delivery of nanotherapeutics. Ultimately, the general strategy of coating biomaterials with immunomodulatory molecules to evade immune response to implanted materials may improve the efficacy of numerous medical devices.
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Tech ID/UC Case 23713/2013-015-0 Related Cases 2013-015-0
美国
