Directed Evolution Of AAV Vectors That Undergo Retrograde Axonal Transport

AAV can be endowed with robust retrograde functionality through directed evolution  Up to two orders of magnitude  increase in retrograde transport over existing variants Efficiency  comparable to synthetic tracers in many circuits Payload  expression levels are sufficient for circuit interrogation  and gene manipulation

Gene therapy, including the treatment of neurodegenerative disorders characterized by pathological spread through functionally connected and highly distributed networks.

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WO2017218842

Additional Technologies by these Inventors

• Ultrasound Contrast Agents Based On Biological Gas Nanoparticles
• Hydrogels For Cell Derivation and Transplantation
• 3D System For Differentiation Of Oligodendocyte Precusors From Pluripotent Stem Cells
• Self-Inactivating Targeted DNA Nucleases For Gene Therapy
• Novel 3D Stem Cell Culture Systems

Tech ID/UC Case

25943/2016-193-0

Related Cases

2016-193-0

美国

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