Engineering Enhanced Retroviral Vectors Through The Insertion Of A His6 Tag Into Vsv-g
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Patent Number: US8163893B2
Application Number: US2008279171A
Inventor: Schaffer, David V. | Yu, Julie H.
Priority Date: 15 Feb 2006
Priority Number: US8163893B2
Application Date: 5 Feb 2009
Publication Date: 24 Apr 2012
IPC Current: C07H002104 | C12N001500 | A01N006300
US Class: 5360234 | 4353201 | 53602372
Assignee Applicant: The Regents of the University of California
Title: Pseudotyped retroviral vectors and methods of use thereof
Usefulness: Pseudotyped retroviral vectors and methods of use thereof
Summary: For production of a pseudotyped retroviral vector; useful for delivering a gene product into an individual (claimed), useful for encoding proteins for the treatment of endocrine, metabolic, hematologic, cardiovascular, neurologic, musculoskeletal, urologic, pulmonary and immune disorders; including inflammatory diseases, autoimmune, chronic and infectious diseases; such as acquired immunodeficiency syndrome (AIDS), cancer, hypercholesterolemia, insulin disorders such as diabetes, growth disorders, various blood disorders including various anemias, thalassemias and hemophilia; genetic defects such as cystic fibrosis, Gaucher's disease, Hurler's Disease, adenosine deaminase (ADA) deficiency, and emphysema.
Novelty: New nucleic acid for production of pseudotyped retroviral vector for delivering gene product comprises nucleotide sequence encoding recombinant viral envelope protein that comprises rhabdovirus envelope protein and heterologous polypeptide
诊断/治疗
癌症/肿瘤
8163893
Tech ID/UC Case 17317/2004-010-0 Related Cases 2004-010-0
美国
