A transgenic Ngal reporter mouse detects kidney injury in real time
Jonathan Barasch, M.D. Ph.D.
Allows real time monitoring of kidney injury by bioluminescence and fluorescence.Obviates the need for serial serum and urine collection.Levels of Ngal increase in response to kidney injury at a much earlier time point.Urinary Ngal is secreted from cells of the kidney tubule as another marker of injury.In the context of kidney injury, Ngal more specifically reflects changes in kidney anatomy, whereas creatinine can confuse the diagnosis by rising due to extra-renal factors.
High-throughput in vivo screening of potential nephrotoxins in real time.High-throughput in vivo screening of potential reno-protective agents/therapeutics in real time.A more sensitive research model for renal disease progression, especially at earlier stages of injury.
Jonathan Barasch, M.D. Ph.D.
美国
