Chimeric Tumor Suppressor Gene and Protein
Lead Inventors: Paul B Fisher, Ph.D.Problem or Unmet Need:Tumor suppressor genes are genes that protect a cell from one step on the path to cancer. The discovery and understanding of tumor suppressor genes led to the development of new kinds of cancer therapies. The technology discovered a novel tumor suppressor gene and its protein with cancer growth suppressing and apoptosis inducing properties by simple genetic recombination techniques, which could have big impact on anti-cancer therapies. The technology developed a novel chimeric tumor suppressor gene, comprising portions of the rat PEG-3 gene fused with portions of human GADD34 gene, exhibiting anti-proliferative activity when expressed in transformed cells. The technology also provides other rPEG3/hGADD34 chimeras, and the use of such genetic modified proteins in inhibiting cell proliferation, angiogenesis, and tumor growth.
The technology provides a method of reversing the action of genes that normal induce cancer promoting properties to genes that now display cancer suppressive properties The technology provides a simple flexible method to construct chimeric tumor suppressor genes and proteins with specific properties
The technology provides a novel tumor suppressor gene and protein that can be used to treat cancers by inducing growth arrest, apoptosis or inhibiting angiogenesis The technology provides a method to construct chimeric tumor suppressor genes and proteins with specific functions
The technology developed a novel chimeric tumor suppressor gene, comprising portions of the rat PEG-3 gene fused with portions of human GADD34 gene, exhibiting anti-proliferative activity when expressed in transformed cells. The technology also...
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