Homeodomain protein code specifying progenitor cell identity and neuronal fate in the ventral neural tube
Lead Inventors: Thomas M. Jessell Ph.D.Methods for generating genetically engineered neurons for treating subjects having a motor neuron injury or a motor neuron disease are described.The method involves implanting genetically engineered neural cells in the injured/diseased neural tissue of the subject. Retroviral expression systems are administered which are capable of expressing the appropriate homeodomain protein. A method of determining whether a chemical compound affects the generation of a motor neuron from a neural stem cell is also provided. The invention provides insights into how extracellular signals are interpreted during the patterning of other vertebrate tissues. The invention further provides a method of treating a subject having a motor neuron injury or a motor neuron disease.
Methods for generating genetically engineered neurons for treating subjects having a motor neuron injury or a motor neuron disease are described.The method involves implanting genetically engineered neural cells in the injured/diseased neural t...
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