Viral and Fungal Inhibitors
Compounds of the invention offer new therapeutic leads in a disease area that lacks any approved therapies.This class of inhibitor compounds has not been previously described in the literature to be inhibitors of West Nile virus protease.
A new compound class that may be used for the treatment of flavivirus infections, including dengue, West Nile virus and encephalitis, has been discovered. At present there are no drugs or vaccines available that are indicated for the treatment and/or prevention of these diseases. Specific compounds of this invention exhibit significantly greater than 80% inhibition of West Nile virus protease, and thus represent an exciting opportunity to capture a growing disease area that is in dire need of new therapies.
美国
