Ubiquitination by a Single Enzyme
Researchers at Purdue University have demonstrated that L. pneumophila can override ubiquitination signaling in host cells with its own enzymes, including members of the SidE effector family. While ubiquitination is generally catalyzed by a cascade requiring the E1, E2, and E3 enzymes, members of the SidE family of bacterial enzymes are capable of performing ubiquitination independent of this cascade. Following this discovery of ubiquitination catalyzed by a single enzyme, this enzyme, SidE, and various SidE constructs hold promise as new tools for research and development in biotechnology.
Performs ubiquitination with a single enzyme
Protein research Bacterial and viral research Biotechnology
Zhao-Qing LuoLuo LabPurdue Biological Sciences
United States
None
美国
