Paper Spray Ionization Without Applied Voltage
Researchers at Purdue University discovered a system configuration that enables Paper Spray to generate ions for analysis without any voltage source (0 voltage Paper Spray). Solvent is supplied to a porous material, interacts with a sample within the porous material, and flows to the tip of the porous material. Given a short distance between the tip of the porous material and the inlet of the mass spectrometer, the solvent (now containing one or more analytes of the sample) flows from the porous material into the inlet of the mass spectrometer. Random charging during the breakup of droplets occurs, generating sample ions, which are analyzed within the mass spectrometer. In that manner, systems of the invention generate and analyze ions of a sample without the application of voltage to the porous material.
Paper Spray ionization without applied voltage Favorable for certain applications, for example those involving live subjects
Mass spectrometry Chemical analysis
R. Graham CooksPurdue ChemistryAston Labs
United States
N/A
美国
