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Novel Orally Available Treatment for Metabolic Syndrome & T2D
技术优势
- Identified, designed and developed merged pharmacophore for sEH/PPAR dual modulators as a unique therapeutic approach- Novel dual modulators are orally available- Favorable absorption, distribution, metabolism and excretion properties- Avoid multidrug regimens and associated unpredictable drug-drug interactions- Modulation of PPAR╬│ regulates lipid metabolism, glucose homeostasis, anti-inflammatory processes- Modulating sEH/ has multiple cardio and kidney protective properties- Lead candidate decreases blood glucose and insulin resistance, improves heart function, prevents development of hypertension and end organ damage in spontaneously hypertensive obese rats (SHROB)
详细技术说明
None
国家/地区
美国
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