Allosteric Modulators of CB1 Cannabinoid Receptors
The modulator:ΓÇóIs a heterocyclic derivativeΓÇóIs more site-specific than conventional therapeutic agentsΓÇóWorks by acting at a site topographically distinct than an orthosteric siteΓÇóHas minimal or no abuse potential as compared to conventional agentsΓÇóWould be commercially useful for treatment of various disorders such as central pain, peripheral pain, neuropathic pain, neuropathy, inflammatory pain, neurodegenerative diseases including multiple sclerosis, mental disorders such a schizophrenia and depression, mood disorders, memory disorders, addiction disorders, eating disorders (anorexia nervosa, bulimia nervosa, binge eating disorders), gastric motility disorders, anorexia related to chemotherapy and HIV, nausea associated with cancer chemotherapy, and glaucoma
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美国
