Drawing Collagen Fibers From a Solution of Monomers
The procedure:ΓÇóIs highly repeatableΓÇóEffectively allows for a strain directed assembly of collagen fibrilsΓÇóAllows for an assembly of highly organized and aligned collagen fibrilsΓÇóEnables the use of a solution/air interface to generate the required strainΓÇóIs highly customized, enabling change of collagen concentration ranges, magnitude/distribution of strain and the rehydration environmentΓÇóAllows for a fiber drawing rate of 1micron/sec to 1cm/secΓÇóAllows for the concentration of accumulated monomers in the preferred range of 2.4-100 mg/mlΓÇóEnables an adjustment of key process parameters such as temperature, ionic strength, pH and buffersΓÇóWould be commercially useful for various applications such as:o Fabrication of connective tissueso Organized scaffolding for regenerative medicineo Tissue repairo Alignment guide for other molecules such as carbon nanotubes
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美国
