A-11 Neuronal Cell Death Inhibitor and Screening Method
Useful to search new compounds suppressing neuronal damage in a various conditions.The newly synthesized carbenoxoloneprodrug(Compound B) effectively suppressed glutamate release by activated microglia, and suppressed microglialneruotoxicity. Compound B could ameliorate disease progression of model animals for various neurodegeneration. The compound, thus, could be a candidate for treating neuronal degeneration in a variety of neurological disorders.
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Inventor: LEE, DANIEL H S | SAH, DINAH W Y | SO, KWOK FAI | WU, WUTIAN
Priority Number: CN101426512A
IPC Current: A61K003800 | A01N003718 | A01N006100
Assignee Applicant: Biogen Idec Ma Inc. |The University of Hong Kong
Title: Methods of treating conditions involving neuronal degeneration | Method of treating diseases referring to neuronal degeneration
Usefulness: Methods of treating conditions involving neuronal degeneration | Method of treating diseases referring to neuronal degeneration
Summary: The methods are useful for promoting regeneration or survival of a sensory neuron in a mammal displaying signs or symptoms of a condition involving neuronal cell death, and for treating hearing loss or an optical neuropathy in a mammal (claimed).
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