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修飾的B-肉酰胺酶及其應用

总结

希望有一种能针对一组不同的β－内酰胺类抗生素筛选细菌以鉴定β－内酰胺酶的工具。一种将指示分子导入β－内酰胺酶而形成的生物传感器可达到该目的，但要求导入的指示分子基本上不会削弱蛋白质结合的亲和力，以保证较高的灵敏度。本发明研发了一种经修饰的β－内酰胺酶，该β－内酰胺酶的Ω环上或Ω环的外侧但接近其活性部位的残基被活性残基置换。

附加资料

Inventor: Thomas Y. Leung | Kwokyin Wong | Pakho Chan
Priority Number: CN1784493B
IPC Current: C12N001555 | A61P003104 | C07K000113 | C07K001400 | C12N000986 | C12N001565 | G01N0033573 | G01N003368
Assignee Applicant: Univ Hongkong Polytechnic
Title: Modified beta-lactamases and uses thereof | The modified beta-lactamase and its application
Usefulness: Modified beta-lactamases and uses thereof | The modified beta-lactamase and its application
Summary: The modified β-lactamases can be used in the detection of β-lactam antibiotics and β-lactamase inhibitors (claimed).
Novelty: New beta-lactamase with a non-reactive residue replaced by a reactive residue, useful for detecting beta-lactam antibodies and beta-lactamase inhibitors or in screening bacteria for beta-lactamases against a panel of beta-lactam antibodies

主要类别

生物医学

细分类别

医学影像

申请日期

41297

申请号码

13/747,679

其他

WONG K.Y.黄国贤
LEUNG Y.C.托马斯·润松·梁
CHAN Pak-ho陈百豪
LEUNG Y.C.
CHAN Pak-ho

国家/地区

中国内地