16-member Ring Matel Chelate
Metal chelates are useful for improving the contrast of X-ray, ultrasound, radionuclide and magnetic resonance (MR) images. However, the metal complexes must be stable and inert so that toxicity resulting from dissociation in the body can be minimized. This invention provides 16-member ring metal chelates that can provide a charge balanced metal complex having improved stability, especially for gadolinium(III) and samarium (III).
Patent Number: US7557205B2
Application Number: US2004948458A
Inventor: Wong, Kwok-Yin | Huang, Chi | Kwok, Cheuk-Sang | Snieckus, Victor
Priority Date: 24 Sep 2004
Priority Number: US7557205B2
Application Date: 24 Sep 2004
Publication Date: 7 Jul 2009
IPC Current: C07B004700
US Class: 540145
Assignee Applicant: The Hong Kong Polytechnic University
Title: 16-member ring metal chelate
Usefulness: 16-member ring metal chelate
Summary: (I) are useful for improving the contrast of X-ray, ultrasound, radionuclide or magnetic resonance (MR) images. (I) are ligands for metal ions, particularly gadolinium and samarium.
Novelty: New metal chelates comprising 1,5,9,13-tetraazacyclohexadecane derivatives, useful for improving the contrast of X-ray, ultrasound, radionuclide or magnetic resonance images
生物医学
医学影像
40714
13/163,764
KWOK Cheuk-sang
WONG Kwok-yin
SNIECKUS Victor (Queen's Univ
美国
