用於對細胞進行損傷處理的機械損傷器
Mechanical cell wounder device and related method
This is a novel device and method for uniform cellular manipulation with economies of scale and operational uniformity. It introduces a multi-channel mechanical damaging device which is used for damaging cells and which comprises a pin support body, a plurality of pins, which are arranged in parallel and connected with the pin support body, and a handle which is connected with the pin support body; the length the pins extending out of the pin support body can be adjusted. The pin support body is provided with a plurality of holes; the pins can be inserted into the holes and are suitable for the one-time suction head which can be replaced. The multi-channel mechanical damaging device can also be provided with guide components, which are arranged on two sides of the pin support body; and the angle between the guide components can be regulated. In particular, the invention provides an 8-channel mechanical damaging device which can be used in the cell injury experiment of cells which are cultured by 96-hole microplate. It also provides a method which uses the multi-channel mechanical damaging device to damage the cell culture and an application thereof in cell migration and the potential biological phenomena thereof.
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Inventor: White, Steven M. | Claycomb, William C.
Priority Number: US7960173B2
IPC Current: C12N000500 | C12N0005077 | C12N001585 | C12Q000168
US Class: 435325 | 5360231
Assignee Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College,Baton Rouge
Title: Cardiac conduction system cells and uses thereof
Usefulness: Cardiac conduction system cells and uses thereof
Summary: The pure population of primitive cardiac pacemaking cells expressing GATA6 is useful in treating cardiac arrhythmias (claimed).
Novelty: New pure population of primitive cardiac pacemaking cells expressing GATA6, useful in preparing a composition for treating cardiac arrhythmias
生物医学
医药成分
2007.07.03
200710127846
Filed
G01/YY/Mech/CN01
香港
