Berberine Alkaloid as a Medicament for Prevention and Treatment of Neural Disease
The present invention is directed to method of preventing or treating neural disease such as Alzheimer’s disease or inhibiting accumulation of β-amy-loid plaques in a subject by administering an effective dosage to the subject an agent (berberine) which inhibits the accumulation of β-amy-loid plaque, phosphor-amyloid precursor protein (p-APP) and tau hyperphosphorylation in a mammalian brian.
Good efficacy
Treat or prevent Neural disease such as Alzheimer’s disease
It relates to a berberine 5,6-dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium) alkaloid and their use as therapeutic agent, particularly in the prevention and treatment of neural disease. Also, it is directed to therapeutic effect of berberine on Alzheimer’s disease by reducing Aβ deposits, tau hyperphosphorylation, gliosis and cognitive impairments.
Patent Number: US20130237556A1
Application Number: US13798066A
Inventor: LI, Min | DURAIRAJAN, Siva Sundara Kumar | LIU, Liangfeng | LU, Jiahong
Priority Date: 12 Mar 2012
Priority Number: US20130237556A1
Application Date: 12 Mar 2013
Publication Date: 12 Sep 2013
IPC Current: A61K00314745
US Class: 514280 | 546048
Assignee Applicant: Hong Kong Baptist University
Title: BERBERINE ALKALOID AS A MEDICAMENT FOR PREVENTION AND TREATMENT OF NEURAL DISEASE
Usefulness: BERBERINE ALKALOID AS A MEDICAMENT FOR PREVENTION AND TREATMENT OF NEURAL DISEASE
Summary: For preventing or treating neural diseases such as neural degenerative diseases, neural mood disorders, bipolar disorder, schizophrenia, depression, Tourette syndrome, attention deficit hyperactivity disorder (ADHD), neuropsychiatric conditions, Alzheimer's disease, cerebreal amyloid angiopathy and dementia in a subject (preferably human); where the neural diseases are associated with abnormal protein aggregation or deposit in the nervous system generated by accumulation of amyloid β -peptide (Aβ ), tau hyperphosphorylation and gliosis, where the abnormal protein aggregation or deposit comprise paired helical filaments-1 (PHF-1), AT8 or AT180 and are found in the brain (all claimed).
Novelty: Composition for preventing or treating neural diseases e.g. schizophrenia, Alzheimer's disease, dementia, depression comprises berberine or its salt or derivative, where compound is isoquinoline alkaloid isolated from natural source
诊断/治疗
其他疾病
2013.03.12
Published
G06/LM/Berb/US01
香港
