Method For Inhibiting Cancer Using Arsenic Trioxide
The Invention Provides A Method For Treating Cancers That Are Dependent On Cyclin D1 For Proliferation, Survival, Metastasis And Differentiation, Involving Administering A Composition Containing An Effective Amount Of Arsenic Trioxide To An Affected Patient. The Arsenic Trioxide Can Be Administered Orally, For Example, As A Solution, Suspension, Syrup, Emulsion, Tablet, Or Capsule. The Composition Can Also Contain One Or More Pharmaceutically Acceptable Carriers And/Or Excipients.
Inventor: Kwong, Yok-Lam
Priority Number: US20080089951A1
IPC Current: A61K003336 | A61P003500
US Class: 424623
Assignee Applicant: The University of Hong Kong
Title: Method for Inhibiting Cancer Using Arsenic Trioxide
Usefulness: Method for Inhibiting Cancer Using Arsenic Trioxide
Summary: The method is useful for promoting cytokine receptor such as interleukin-6R or receptor tyrosine kinase degradation in cancer cells, where the cancer includes cancer dependent on receptor tyrosine kinase and cytokine receptor for development, progression, proliferation, differentiation or metastasis, epidermal growth factor receptor (EGFR) dependent cancer, head and neck squamous cell carcinoma (HNSCC) and multiple myeloma (all claimed).
Novelty: Method for promoting cytokine receptor e.g. interleukin 3 receptor or receptor tyrosine kinase degradation in cancer cells, involves contacting cells with arsenic trioxide to down regulate cytokine receptor
诊断/治疗
癌症/肿瘤
香港
