Uses of transgenic animals containing a type X collagen mutant
This invention provides an isolated DNA comprising the sequence which codes for a mutated collagen X or a portion thereof wherein the expression of said DNA regulates bone growth. This invention provides a polypeptide encoded by the isolated DNA comprising the sequence which codes for a mutated collagen X or a portion thereof wherein the expression of said DNA regulates bone growth. This invention also provides a polypeptide which comprise the portion of the mutated collagen X capable of regulating bone growth. This invention further provides a transgenic animal comprising an isolated DNA comprising the sequence which codes for a mutated collagen X or a portion thereof wherein the expression of said DNA regulates bone growth.
Inventor: CHEAH KATHRYN | CHEUNG KENNETH
Priority Number: AT290596T
IPC Current: A01K0067027 | C07K001478 | C12N001512 | C12N001585 | A61K003800 | A61K004800
Assignee Applicant: The University of Hong Kong
Title: VERWENDUNG TRANSGENER TIERE, DIE EINE MUTATION DES COLLAGEN X ENTHALTEN
Usefulness: VERWENDUNG TRANSGENER TIERE, DIE EINE MUTATION DES COLLAGEN X ENTHALTEN
Novelty: Col10-13del DNA encoding mutated collagen X polypeptide, useful for treating a subject afflicted with dwarfism, osteoporosis and for improving speed of bone union after fracture
生物医学
DNA /基因工程
香港
