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A-47 Photo-responsive oligonucleotide

Technology Benefits

ΓùÅ The cis-form of S-Azo is more stable than Azo.ΓùÅ The wavelength at absorption maximum (╬╗max) becomes larger by using S-Azo, and the DNA duplex photoisomerization occurs in visible lights. .ΓùÅ 400nm light accelerates to form cis-form and 450nm to form trans-form.ΓùÅ The larger Γè┐Tm makes the hybridization of oligonucleotides more efficient.

Technology Application

ΓùÅ Reversibly controllable DNA-enzyme and Ribozyme (A light-switching for m-RNA splicing) .ΓùÅ Photo-responsive DNA nanomachineΓùÅ Gene expression control by light (A light-controlled transcription by T7 RNA polymerase)ΓùÅ Nano capsule which opens and closes by light

Detailed Technology Description

None

Supplementary Information

Inventor: ASANUMA Hiroyuki | LIANG Xingguo | KASHIDA Hiromu | NISHIOKA Hidenori | FUJII Taiga | ISHIKAWA Teruchika
Priority Number: WO2012029434A1
IPC Current: C07H002100 | C12N001509
Assignee Applicant: National University Corporation Nagoya University
Title: OLIGONUCLEOTIDE AND USE THEREOF | OLIGONUCLÉOTIDE ET UTILISATION DE CELUI-CI
Usefulness: OLIGONUCLEOTIDE AND USE THEREOF | OLIGONUCLÉOTIDE ET UTILISATION DE CELUI-CI
Summary: The oligonucleotide is useful for as agent for controlling formation and dissociation of double chain (claimed).
Novelty: New oligonucleotide comprising azobenzene derivative used as agent for controlling formation and dissociation of double chain, comprises azobenzene derivative

Industry

Chemical/Material

Sub Group

Chemical/Material Application

Country/Region

USA

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