Methods of controlling the size and aggregate formation of nanoparticles
Size-dependent properties of nanoparticles can be modified to suit specific utilities in medicinal applications, such as mobility, membrane permeability, and capacity to hold drug and/or signaling molecules Enhancement of nanoparticle-mediated imaging signals can be achieved under precise control The size of nanoparticles and the extent of nanoaggregates can be specified to obtain uniform nanoparticle products
Enhancement or modification of the amount of signals emitted by dye-conjugated nanoparticles used in biomedical imaging or environmental analysis Manipulation of drug-bearing capacity and mobility of nanoparticles used in drug delivery
This is an opportunity to license a set of nanoparticle technologies to produce uniform silica nanoparticles of desired sizes and to form nanoparticle aggregates of preferred shape. Use of nanoparticles has been increasingly adopted for medical applications, such as drug delivery and imaging. For example, nanoparticles containing drug or dye molecules can be conjugated with biological molecules, such as antibodies or receptors, to respectively deliver the drug or emit signals at specific target sites. The extent of nanoparticlesΓÇÖ drug-carrying capacity, mobility or signal emission can be modified by changing the size and aggregate formation of the nanoparticles, but it is difficult to precisely and uniformly manipulate theses parameters using currently known methods. Our nanoparticle technologies employ defined chemical manipulations to create uniform nanoparticles and nanoaggregates of a selected size and shape. These methods provide a simple and inexpensive approach to modify the properties of nanoparticles as needed for particular applications.
Patent Number: US20100140548A1
Application Number: US2009378093A
Inventor: Zhao, Julia Xiaojun | Xu, Shuping
Priority Date: 11 Feb 2008
Priority Number: US20100140548A1
Application Date: 11 Feb 2009
Publication Date: 10 Jun 2010
IPC Current: C09K001159
US Class: 25230140R
Title: Nanoaggregate composition and method for making
Usefulness: Nanoaggregate composition and method for making
Summary: The method is useful for preparing nanoaggregate.
Novelty: Preparing nanoaggregate comprises forming nanoparticle cores, forming metal shell on surface of nanoparticle cores, coating nanoaggregate building blocks with concentration of polyvinylpyrrolidone molecules, and producing nanoaggregate
Chemical/Material
Nano Materials
USA
