亞洲知識產權資訊網為知識產權業界提供一個一站式網上交易平台，協助業界發掘知識產權貿易商機，並與環球知識產權業界建立聯繫。無論你是知識產權擁有者正在出售您的知識產權，或是製造商需要購買技術以提高操作效能，又或是知識產權配套服務供應商，你將會從本網站發掘到有用的知識產權貿易資訊。

返回搜索結果

Method for chemical production of enantiomerically pure chiral N-Acyl-a-aminonitriles

總結: New optimized chemocatalytic route for important precursors N-acyl-α-aminonitriles or N-sulfonyl-α-aminonitriles, e.g. of Vildagliptin® or Saxagliptin®.

技術優勢: Effective chemical production process of N-acyl-a-aminonitriles or N-sulfonyl-a-aminonitriles
Enantiomerically pure Gliptin derivatives
New optimized chemocatalytic route
New approach for important precursors, e.g., of Vildagliptin® or Saxagliptin®
Starting material easy accessible and avoiding cyanide or Vilsmeier reagents as toxic reagents

技術應用: Enantiomerically pure N-acyl--aminonitriles gained these days interest in the
pharmaceutical industry since a range of recently developed pharmaceuticals are
based on this product class. Examples are Vildagliptin®, Saxagliptin® or
NVP-DPP-728, which are active pharmaceutical ingredients against diabetes type II

詳細技術說明: Important precursors of are synthesized via multiple phase reactions as state of the art and typical strategies towards such types of molecules are based on toxic reagents such as cyanides or Vilsmeier reagents. The
production of the latter one includes toxic precursors like oxalylchloride and
phosphorylchloride. The present invention focuses on a production process which avoids the need of such toxic reagents. In addition, it has the advantage that the reaction can be conducted under mild conditions

分類: - international:
C07C253/00; C07C255/32; C07D207/16; C07D209/52
- cooperative:
C07B51/00; C07D207/16; C07B2200/07

欲了解更多信息，請點擊這裡