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Thermally Gelling Drug Dispersion Systems

技術優勢

Createfilms using thermally gelling polymers Dispersingpoorly soluble drugs into a liquid phase or pre-formed gelEnsuregel uniformityVarietyof polymers and grades can be used in the formation and release of the gelControlthe release and absorption of the drug using inactive ingredients

詳細技術說明

Novelthermally gelling polymers that are used to produce drug dispersion productssuch as films.

*Abstract

Avariety of polymer types may be used to form a gel, and a variety of grades maybe used to control the release of an active ingredient following administrationto a patient. Poorly soluble drugs (e.g. buprenorphine) can be dispersed in aliquid phase and maintain a uniform dispersion until drying yields a filmproduct. Alternatively, poorly soluble drugs may be incorporated into analready formed gel, and dispersed via suitable agitation.

*Background

Poor solubility affects the ability of a drug to beabsorbed in the body, limiting the amount of the drug available to create theintended action on the body. The Biopharmaceutics Classification System is asystem that categorizes drugs based on solubility and permeability. Many drugson the market suffer from issues with solubility and overall, around 40 percentof all New Chemical Entities (NCEs) have poor solubility. For NCEs, poorsolubility can result in drug development failure. Current approaches forimproving solubility include chemical alteration, solid dispersions, andparticle size reduction. These processes may serve to improve solubility;however, often times these procedures involve increased complexity and cost aswell as poor control of release kinetics. Thus, there exists a present marketneed for increased solubility of drugs to allow for faster and more effectiveaction in the body.

*Inquiry

STC has filed intellectual property on this exciting new technology and is currently exploring commercialization options. If you are interested in information about this or other technologies, please contact Arlene Mirabal at amirabal@stc.unm.edu or 505-272-7886.

國家/地區

美國