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Novel Antibody Fragments for the Treatment of Biofilm-Associated Disease

詳細技術說明: Inventors at Nationwide Children’s Hospital have developed novel antibody fragments to disrupt biofilms of diverse bacterial species.

*Abstract: Biofilms are surface-attached communities of microorganisms that play a critical role in the vast majority of chronic and recurrent infectious diseases. The CDC and the NIH recently estimated that biofilms are responsible for 65% to 80% of all infections. DNABII proteins and extracellular DNA (eDNA) are integral to the structural integrity of biofilms formed by all human bacterial pathogens tested to date. The major challenge with bacterial biofilms is the inability of the host immune system and/or antibiotics and other antimicrobials to gain access to the bacteria protected within the biofilm. Inventors at Nationwide Children’s Hospital have developed novel antibody fragments to disrupt biofilms of diverse bacterial species.

*Inquiry: Kyle Murrah, Ph.D. The Research Institute at Nationwide Children's Hospital Office of Technology Commercialization 700 Children's Drive Columbus OH 43205 T: 614 355-4551 F: 614 722-2716 Kyle.Murrah@nationwidechildrens.org

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