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Novel GPCR, Membrane Antigen, and Cyclin D Proteins from KSHV

*Abstract: Kaposi's sarcoma-associated herpes virus (also referred to as KSHV or human herpes virus 8 HHV-8) plays a pathogenic role in the development of some malignant lymphomas.

The inventors have identified and/or sequenced three proteins of KSHV: an antigenic membrane protein; a G protein coupled receptor; and a cyclin protein. The invention provides isolated nucleic acid molecules encoding these proteins as well as antisense molecules and ribozymes derived therefrom.

The proteins may be targets for drug discovery efforts; the membrane protein or GPCR could provide antigens for a vaccine.

其他

Cesarman E, et al (1996) Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma, J Virol. 70(11): 8218-23.
NCBI Nucleotide listing for for membrane antigen, GPCR, and cyclin D: U40394
Reed JA, et al (1998) Demonstration of Kaposi's sarcoma-associated herpes virus cyclin D homolog in cutaneous Kaposi's sarcoma by colorimetric in situ hybridization using a catalyzed signal amplification system, Blood 15;91(10): 3825-32.

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