Novel Gadolinium-Free MRI Contrast Agents
- 技術應用
- These nanoparticles have the potential to be used for various applications in diagnostic radiology and imaging, due to their enhanced relaxivity, and long-term stability in biological media. Moreover, this technology enhances positive contrast of MR imaging in uptake by Hela cells.
- 詳細技術說明
- Researchers from UC San Diego have developed new polycatechol nanoparticles potentially suitable for pre-clinical investigations as gadolinium-free, safe, and effective imaging agents for MRI contrast enhancement. This technology comprises a new class of biocompatible MRI contrast agents based on micellar nanoparticles formed by amphiphilic poly(Fe(III)-catecholate)-based copolymers. Compared with established natural and synthetic melanin-based T1 agents, this new approach of using well-defined amphiphilic tri-block copolymers via a controlled living polymerization method could generate different self-assembled shaped nanoparticles with rigorously controlled physical parameters. This technology exhibits good r1, low r1/r2 ratio, superior stability in blood serum, and excellent in vitro MRI performance in cells.
- *Abstract
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Current FDA contrast agents usually involve heavy metals such as gadolinium (Gd).
However, the slow clearance of Gd-based chelates may induce several severe diseases (i.e. nephrogenic systemic fibrosis). Many labs are looking for alternatives that don't involve this metal.
- *IP Issue Date
- Dec 29, 2016
- *Principal Investigation
-
Name: Nathan Gianneschi
Department:
Name: Yuran Huang
Department:
Name: Yiwen Li
Department:
Name: Miriam Scadeng
Department:
- 其他
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State Of Development
UC San Diego is seeking licensees to develop this promising technology into commercial applications in diagnostic radiology and nanoprobe imaging
Related Materials
Tech ID/UC Case
25928/2015-295-0
Related Cases
2015-295-0
- 國家/地區
- 美國
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