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An Implantable Cortical Linear-Array Electrode for Improving the Signal Quality of Isolated Neurons in the Cortical Tissue Layers of Primates

詳細技術說明

Scientists at UC San Diego have designed a laminar electrode capable of recording isolated unit activity throughout all layers of a primate’s cortex. This technology is able to readily differentiate layers while recording the responses of different types of neurons in specific cortical layers, permitting better neuron classification (e.g., inhibitory neurons versus pyramidal neurons). Employing this technology, researchers may readily investigate how the stimulus-evoked flow of activity throughout a cortical column is influenced by attention state.

*Abstract

Technology that employs optical imaging of cortical neuronal activity is generally perceived as the future of functional neurophysiology, however optical recording of neuronal activity in the middle and lower layers of the cortex, as well as anatomically deeper areas of the brain are inaccessible to such technology. This makes electrophysiological technology, (i.e. laminar electrodes) that can access greater depths of cortical and sub-cortical structures valuable for academic and clinical applications. In the academic realm there is a distinct lack of studies that demonstrate the interaction of single neurons that exist among different cortical layers. This is largely due to the limitations of existing laminar electrodes that are either too fragile or traumatize neural tissue when inserted into the cortex.

*Principal Investigation

Name: John Curtis

Department:

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Tech ID/UC Case

21592/2011-084-0

Related Cases

2011-084-0

國家/地區

美國