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Substituted quinolone carboxylic acids and potential therapeutic effects in CNS disorders

技術優勢

- The compounds are highly selective for GABA sub A receptor. - The compounds binds to a unique site on GABA sub A receptor.

技術應用

Treatment of CNS disorders related to the modulation of GRC.

詳細技術說明

GABA sub A receptor complex (GRC) is ubiquitously expressed throughout the CNS with almost all neurons staining for their presence. It provides majority of the fast inhibitory synaptic transmission regulations. It is well-documented that modulation of the GRC can ameliorate anxiety, seizure activity, and insomnia. However, none of the known drugs are selectively modulate GRC without sides effects. Researchers at UCI invented substituted quinolone carboxylic acids and their derivatives that bind to GRC at a unique site. The compounds can be used potentially to treat and/or prevent a variety of CNS disorders related to abnormal activities of GRC. Such diseases could be acute and chronic pain, depression and bipolar disorder, etc.

*Abstract

Substituted quinolone carboxylic acids and their derivatives modulate the effect of γ-aminobutyric acid (GABA). It could be used to ameliorate CNS disorders related to GABA receptors.

*IP Issue Date

Apr 8, 2008

*Principal Investigation

Name: Kelvin Gee

Department:

Name: Derk Hogenkamp

Department:

Name: Timothy B C Johnstone

Department:

申請號碼

7355047

其他

State Of Development

The compounds has been tested in animals studies.

Tech ID/UC Case

24922/2002-440-0

Related Cases

2002-440-0

國家/地區

美國