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Ligands for Catalyzing Chemical Reactions

標題

Catalysts Containing N-Hetercyclic Carbenes for Enantioselective Synthesis

詳細技術說明

None

*Abstract

Combines Carbene Ligands with Transition Metals to Catalyze Safer and Less Toxic Products

These metal complexes supported by carbene ligands are cheaper and more effective alternatives to phosphine ligands for catalyzing chemical reactions. Phosphine ligands attached to transition metals are common catalysts in the pharmaceutical industry and in other chemical applications. Unfortunately, phosphine ligands can be toxic and are often unstable. Thus, there is always a need for cheaper, cleaner, more stable, efficient, and selective catalysts.

Researchers at the University of Florida have developed catalysts that meet this need using carbene ligands. These catalysts are far less expensive and toxic, as well as modular and more selective than phosphine ligands.

Application

Carbene ligand compounds that catalyze chemical reactions

Advantages

• Catalyzes reactions using cheaper chemical compounds, decreasing overall cost
• Creates exceptionally strong bonds to transition metals, preventing catalyst degradation, prolonging catalyst lifetimes, and improving efficiency
• Lowers toxicity compared to phosphine ligands, improving safety of chemical reactions and consumer product synthesis
• Reduces difficulty associated with modifying and fine-tuning catalysts, enabling market adoption in a wide range of applications

Technology

These carbene ligands combine with transition metals to catalyze a wide variety of reactions to produce safer and less toxic products. For example, in pharmaceutical drug production, these ligands produce only one enantiomer of a chiral compound. This is advantageous because drugs typically have two enantiomers, with the non-toxic one being responsible for healing effects and the toxic one causing harmful side effects. Eliminating the toxic one thus eliminates side effects. Furthermore, these carbene ligands increase the efficiency of chemical reactions when compared to phosphine ligands because they give higher yields and catalyze a wider variety of reactions.

*IP Issue Date

Jun 4, 2013

*IP Publication Date

Nov 18, 2010

*Principal Investigation

Name: Adam Veige

Department:

Name: Khalil Abboud

Department:

Name: Mathew Jeletic

Department:

Name: Roxy Swails

Department:

附加資料

Inventor: ZHI, Zhi-ming | HUANG, Wenjian
Priority Number: CN1934115A
IPC Current: C07D048722 | B01J003118 | B01J003126 | B01J003128 | B01J003132 | C07D030106 | C07D030112 | C07D030114 | C07D030119 | C07D040506
Assignee Applicant: The University of Hong Kong
Title: Diastereoselective epoxidation of allylically substituted alkenes using metalloporphyrin catalysts | A non-stereoscopic selective epoxidation of the allylic substitution olefin with the porphyran catalyst
Usefulness: Diastereoselective epoxidation of allylically substituted alkenes using metalloporphyrin catalysts | A non-stereoscopic selective epoxidation of the allylic substitution olefin with the porphyran catalyst
Summary: Used in the preparation of trans-/erythro-epoxide (claimed), which is useful in the synthesis of natural products and chiral drugs.
Novelty: Preparation of a trans-/erythro-epoxide, which is useful in the synthesis of natural products and chiral drugs, comprises catalyzing the reaction of an oxidant with the alkene compound in the presence of metalloporphyrin catalyst

主要類別

化工/材料

細分類別

化工/材料應用

申請日期

Jan 20, 2010

申請號碼

8,455,661

其他

國家/地區

美國