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Skeletal stem cell for the regeneration of cartilage and bone and treatment of osteoarthritis: the osteochondroreticular stem cell

總結

This technology describes the identification of a skeletal stem cell and the means to isolate and expand it, for use in the regeneration of cartilage and bone due to skeletal disorders such as osteoarthritis, osteoporosis, and bone fracture. Osteoarthritis is a chronic, debilitating condition affecting more than 250 million people worldwide. Current approaches for the treatment of osteoarthritis are arthroscopic inspection and clearing of joint debris, eventually followed by a total joint replacement. The envisioned clinical application for these cells is delivery at the time of arthroscopy, where the cells could provide enormous therapeutic benefit, minimizing patient pain and delaying or obviating the need for a total joint replacement. The ability to identify and separate out these cartilage-making cells is a powerful tool that may change the standard of care for the treatment of joint pain and other skeletal disorders.

技術優勢

The cells described in this technology have improved chondrogenic potentialThe cells described in this technology have fewer descendant cell types (i.e. cannot differentiate into adipocytes)Patent Information:Tech Ventures Reference: IR CU15034

技術應用

Treatment for osteoarthritis, osteoporosis, bone fractureStudy skeletal development and skeletal disordersThe methodology of isolation may be used to identify cells with chondrogenic potential from other sources (i.e. synovium)The cells described in this technology may occupy a new population of previously unidentified skeletal stem cells that may have further applications in regenerative medicine and developmental researchTechnology may be applied to cancer research

詳細技術說明

None

*Abstract

None

*Inquiry

Jerry KokoshkaColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR

CU15034

*Principal Investigation

*Publications

Worthley D. et al. "Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential" Cell. 2015 Jan 15;160:269-84.

國家/地區

美國