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In vitro establishment of AIDS-related lymphoma cell lines

技術優勢: Derivation of these cell lines from three distinct patients and tumor locations allows the investigator to study the biological, immunological, or viral factors important for lymphomagenesis. Cell lines are derived from human AIDS-associated lymphoma patients and therefore are events that occur in the clinic, in contrast to cell lines made from transgenes or gene deletion. The researcher can compare and contrast the genetic lesions present in these cell lines to determine if certain types of genetic lesions are present in all tumors, or rather specific to certain types of environmental exposure.

技術應用: In vitro cell lines to study the biological, immunological, and viral factors involved in AIDS-associated lymphomagenesis. In vitro system to determine if lymphoma drugs currently on the market are equally efficacious against AIDS-associated lymphoma. In vitro system to establish if anti-viral treatment is an effective treatment strategy for AIDS-associated lymphoma.Advantage:Derivation of these cell lines from three distinct patients and tumor locations allows the investigator to study the biological, immunological, or viral factors important for lymphomagenesis.Cell lines are derived from human AIDS-associated lymphoma patients and therefore are events that occur in the clinic, in contrast to cell lines made from transgenes or gene deletion.The researcher can compare and contrast the genetic lesions present in these cell lines to determine if certain types of genetic lesions are present in all tumors, or rather specific to certain types of environmental exposure.

詳細技術說明: Lead Inventors: ”Riccardo Dalla-Favera, M.D.”">Riccardo Dalla-Favera, M.D.

*Inquiry: Peter GolikovColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*Publications: Gaidano G, et al. 1993. In vitro establishment of AIDS-related lymphoma cell lines: phenotypic characterization, oncogene and tumor suppressor gene lesions, and heterogeneity in Epstein-Barr virus infection. Leukemia 7: 1621-1629.Further Information: Columbia | Technology VenturesPeter Golikov; MS, MBA ; Tel: (212) 305-9656Email: TechTransfer@columbia.edu

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