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Chimeric Tumor Suppressor Gene and Protein

總結: Lead Inventors: Paul B Fisher, Ph.D.Problem or Unmet Need:Tumor suppressor genes are genes that protect a cell from one step on the path to cancer. The discovery and understanding of tumor suppressor genes led to the development of new kinds of cancer therapies. The technology discovered a novel tumor suppressor gene and its protein with cancer growth suppressing and apoptosis inducing properties by simple genetic recombination techniques, which could have big impact on anti-cancer therapies. The technology developed a novel chimeric tumor suppressor gene, comprising portions of the rat PEG-3 gene fused with portions of human GADD34 gene, exhibiting anti-proliferative activity when expressed in transformed cells. The technology also provides other rPEG3/hGADD34 chimeras, and the use of such genetic modified proteins in inhibiting cell proliferation, angiogenesis, and tumor growth.

技術優勢: The technology provides a method of reversing the action of genes that normal induce cancer promoting properties to genes that now display cancer suppressive properties The technology provides a simple flexible method to construct chimeric tumor suppressor genes and proteins with specific properties

技術應用: The technology provides a novel tumor suppressor gene and protein that can be used to treat cancers by inducing growth arrest, apoptosis or inhibiting angiogenesis The technology provides a method to construct chimeric tumor suppressor genes and proteins with specific functions

詳細技術說明: The technology developed a novel chimeric tumor suppressor gene, comprising portions of the rat PEG-3 gene fused with portions of human GADD34 gene, exhibiting anti-proliferative activity when expressed in transformed cells. The technology also...

*Inquiry: Peter Golikov Columbia Technology Ventures Tel: (212) 854-8444 Email: TechTransfer@columbia.edu

*Publications: Su ZZ, Emdad L, Sarkar D, Randolph A, Valerie K, Yacoub A, Dent P, Fisher PB. Potential molecular mechanism for rodent tumorigenesis: mutational generation of Progression Elevated Gene-3 (PEG-3). Oncogene. (2005) 24(13):2247-2255.

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