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Production of Tissue Engineered Intestine (TEI) to Treat Short Bowel Syndrome

詳細技術說明: Production of tissue engineered intestine (TEI) using a patient’s own cells and a nanofiber scaffold

*Abstract: Short bowel syndrome (SBS) is a consequence of massive small bowel resection performed in patients presenting various diseases. Many thousands of patients with SBS each year depend on total parenteral nutrition (TPN) for survival. The cost for TPN exceeds $50,000 per year per patient; and the mortality rate remains high. Researchers at Nationwide Children’s Hospital have developed a state-of-the-art technology to fabricate tissue engineered scaffolds that mimic the architecture and properties of native intestine and enhance the bio-environment for cell adhesion, proliferation and differentiation. Combining the newly identified and characterized intestinal stem cells (ISC) and enteric neural stem cells (NSC) with this novel nanofiber technology, a full thickness, functional intestine can be generated to treat and manage SBS in neonates, as well as in pediatric and adult patients.

*Inquiry: Kyle Murrah, Ph.D.The Research Institute atNationwide Children's HospitalOffice of TechnologyCommercialization700 Children'sDrive Columbus OH 43205T: 614 722-4551 F: 614722-2716Kyle.Murrah@nationwidechildrens.org

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