亞洲知識產權資訊網為知識產權業界提供一個一站式網上交易平台，協助業界發掘知識產權貿易商機，並與環球知識產權業界建立聯繫。無論你是知識產權擁有者正在出售您的知識產權，或是製造商需要購買技術以提高操作效能，又或是知識產權配套服務供應商，你將會從本網站發掘到有用的知識產權貿易資訊。

返回搜索結果

7-Azaindenoisoquinolines as Anticancer Agents

總結: Researchers at Purdue University have developed a series of 7-azaindenoisoquinoline derivatives that act to inhibit topoisomerase and subsequently induce cell death. This new class of topoisomerase inhibitors has the potential to possess enhanced chemical stability over traditional inhibitors, while increasing inhibitor effectiveness.

技術優勢: Azaindenoisoquinolines have enhanced chemical stability and effectiveness over other TOP1 inhibitorsTOP1 is a proven target for cancer therapy

*Background: Topoisomerase 1 (TOP1) is an important protein found in the cell; it is used to unwind and reduce torsional stress on DNA during replication. TOP1 inhibitors are a useful chemotherapy agent because cells that are constantly dividing, such as cancer cells, are much more susceptible to attack; cell death will occur when topoisomerase 1 is inhibited. TOP1 inhibitors make up a large portion of the chemotherapy market because they can be used to target a wide variety of proliferating tumors. The characteristic of uninhibited division is a common feature in cancer that can be targeted without needing a specific marker for each cancer cell type. As more information becomes readily available, it is becoming apparent that within tumors there is a heterogeneous population of cells populating the primary tumor and the secondary tumors.

*Web Links: Purdue Office of Technology CommercializationPurdueInnovation and EntrepreneurshipMark CushmanPurdue Medicinal Chemistry and Molecular Pharmacology

欲了解更多信息，請點擊這裡